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Carbon Dioxide Therapy in the Treatment of Localized Adiposities:
Clinical Study and Histopathological Correlations
Cesare Brandi, M.D., Carlo D’Aniello, M.D., Luca Grimaldi, M.D., Bruno Bosi, M.D., Iacopo Dei, M.D.,
Piero Lattarulo, M.D., Carlo Alessandrini, M.D.
Siena, Italy
Abstract.
The authors report their experience using carbon
dioxide (CO2) therapy for the treatment of 48 female patients
presenting adipose accumulations, located on the thighs, knees,
and/or abdomen; a Carbomed Programmable Automatic Carbon
Dioxide Therapy apparatus was used. In light of the effects
of CO2 on the microcirculation recently described in the literature,
we expected this gas, which we administered subcutaneously,
to positively affect the physiological oxidative lipolytic
process. The aim of our study was to evaluate the effect of this
therapy on localized adiposities. As such, we describe the
method we used and report the results observed in the areas
treated (in terms of reduction in maximum circumference) as
well as side effects. Furthermore, we assessed the effect of
subcutaneous administration of CO2 on the microcirculation by
showing changes in the Laser Doppler signal and in the concentration
of transcutaneous oxygen tension (tcPO2). Pre- and
posttreatment biopsies of tissues were performed in seven patients
in order to study the changes induced by the use of CO2
on both adipose and connective tissues. All data obtained were
statistically analyzed; values of P < 0.05 were considered significant.
Key words: Carbon dioxide—Cellulite—Localized adiposity
